Medicinal chemistry

Enantia's approach to medicinal chemistry projects is focused on delivering value through the synthesis of those sets of molecules that are not obvious to make and need a dedicated and skilled synthetic team.

We can contribute to your medicinal chemistry projects in the different stages of drug discovery:

• Hit-to-lead. Selected sets of small molecules or analogues can be prepared for hit-to-lead programs.
• Lead optimization. Following a client driven approach we can prepare tailor-designed molecules to improve the potency and drug-like properties of the most promising compounds.
• Widening of libraries' chemical diversity. We can enhance the chemical diversity and exclusivity of your chemical library through the synthesis of non-commercially available screening compounds.
• Intellectual Property protection. Gain wider and stronger IP protection when submitting a patent application expanding the chemical diversity of the exemplified compounds.

The access to state-of-the-art facilities, along with a team of skilled and experienced organic chemists, make us able to meet with strict deadline requirements. The use of parallel synthesis technologies, accelerated organic synthesis by means of microwave chemistry, automated purification equipment and high-throughput analytical techniques allow Enantia's medicinal chemists to ensure that compounds are made rapidly for biological testing in order to provide new data to help the next round of optimization.

Additional tasks we can help you with to move your medicinal chemistry projects forward can be the synthesis of:

• Building Blocks, scaffolds, intermediate compounds
• Reference compounds
• Lead compounds on multigram scale

We are convinced that flexibilty and communication are especially key when dealing with medicinal chemistry projects, always subjected to continuous change due to feedback from biological and ADMET screening. Full adaptation to the client's request is key to the success of the project. Electronic communications are normally made through SFTP (Secure File Transfer Protocol) or through encrypted e-mails (PGP).